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KMID : 0378019940370020081
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New Medical Journal
1994 Volume.37 No. 2 p.81 ~ p.88
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Efficacy and Safty of Sabril^(®) (Vigabatrin) as Add-on Therapy in Pediatric refractory Epilepsy
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Abstract
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A Study was made on 20 cases of refractory. epileptic children who had been observed at the pediatric department of Chungnam National University Hospital during the period from May to December, 1993.
Vigabatrin (40-80mg/kg/d) was used as add-on therapy and I observed the efficacy and safty of Vigabatrin. Study protocol consisted of 2 months of phase I and 2-4 months of phase H . The mean plasma concentration of anticonvuisants before Vigabatrin was within therapeutic´ ranges. 12 patients (60%) had neurologic abnormality. Mean duration of epilepsy was 4.7 years. Among 20 patients, 3 patients (15%) were free from seizure, 6 patients (30%) were marked improved 2 patients (10%) were moderately improved. Among 7 patients of partial seizure, 2 patients (28.6%) were free of seizure, 2 patients (28.6%) were marked improved, 1 patients (14.3%) was moderately improved, 50% of patients with complex partial seizure was marked improved. Among 8 patients of generalized seizure, 3 patients (37.5%) were moderately improved, 50% was aggravated in myoclonic seizure. Among 3 patients of infantile spasm, 2 patients (66.7%) were marked improved. 50% of cases was marked improved in Lennox-Gastaut Syndrome. The side effects of Vigabatrin were shown in 4 cases (20%) of patients, and they were drowsiness (2 cases), dizziness (1 case), headache (1 case) and nervousness (1 case).
My study suggests that Vigabatrin as add on therapy is a useful antiepileptic drug for pediatric refractory epilepsy.
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